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<font face="Arial"><i><b>Getting under the skin: the immunogenetics of 
psoriasis.</b></i></font></p>
<p style="margin-left: 10"><b><font size="2" face="Arial">Bowcock AM, Krueger 
JG.</font></b></p>
<p style="margin-left: 10"><font face="Verdana" size="2">Department of Genetics, 
Washington University School of Medicine, Saint Louis, Missouri 63110, USA. 
Bowcock@genetics.wustl.edu<br>
<br>
Psoriasis is a chronic inflammatory disorder of the skin that is mediated by T 
cells, dendritic cells and inflammatory cytokines. We now understand many of the 
cellular alterations that underlie this disease, and genomic approaches have 
recently been used to assess the alterations of gene expression in psoriatic 
skin lesions. Genetic susceptibility factors that contribute to predisposition 
to psoriasis are now also being identified. It is hoped that we will soon be 
able to correlate the cellular pathogenesis that occurs in psoriasis with these 
genetic factors. In this Review article, we describe what is known about genes 
that confer increased susceptibility to psoriasis, and we integrate this with 
what is known about the molecular and cellular mechanisms that occur in other 
inflammatory and autoimmune disorders.</font></p>
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